Information on the boron-based chemotherapy agent Bortezomib  
 
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Bortezomib Research


Phase I study of bortezomib and cetuximab in patients with solid tumours expressing epidermal growth factor receptor. - An abstract from the University of Minnesota

Results of the APEX Trial: Bortezomib (Velcade®) Delays Progression of Advanced Multiple Myeloma Longer than Standard Therapy

Green tea supplements deactivate bortezomib - a researcher saw "100% inactivation...at levels easily achieved by patients who take green tea supplements, and possibly those who drink large amounts of tea." The polyphenols in the tea are the culprit.

Write-up from NCI's Developmental Therapeutics Program

The role of bortezomib in the treatment of lymphoma

The proteasome inhibitor bortezomib induces apoptosis in human retinoblastoma cell lines in vitro.

Bortezomib in combination with celecoxib in patients with advanced solid tumors

Bortezomib in relapsed or refractory mantle cell lymphoma (MCL): Results of the PINNACLE study.

Bortezomib ups survival of mice with lupus - it eliminated autoantibody production (a problem in autoimmune disorders), attenuated nephritis and improved survival.

Green tea supplements deactivate bortezomib - polyphenols in the tea prevent bortezomib from binding with the target substrate in the malignant cell.

 


Bortezomib molecule structure

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